Sandeep Patnaik
Sri Sathya Sai Institute of Higher Learning, India
Title: Novel nanoformulations for improved therapeutic efficacy of some non-steroidal anti-inflammatory poorly water soluble drugs
Biography
Biography: Sandeep Patnaik
Abstract
One of the major obstacles to the development of highly potent pharmaceutics is the poor water solubility of many drugs. Low water solubility limits the bioavailability and absorption of these agents. By improving the drug release profile of these drugs, it is possible to enhance their bioavailability and reduce side effects. Non-steroidal anti-inflammatory drugs (NSAIDs) although are very effective as pain killers and anti-inflammatory agents, these belong to the type II category of the biopharmaceutical classification system, indicating that, though these drugs have a relatively high membrane permeability, their bioavailability remains limited due to their poor solubility in aqueous media. Formulations of nanodispersions in polymers have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. In these formulations, the drug molecules are dispersed molecularly but irregularly in the hydrophilic carrier and hence the drug remains in its highly energetic amorphous form. Our endeavor would be to tailor make the synthesis routes in a manner that would result in reduction of the polymer dimensions also to nanoscale in an effort to make the dispersions more effective in carrying, stabilizing and releasing the drug particles that are encapsulated. In this work, novel nanoformulations of some of the NSAIDs: Piroxicam, Aceclophenac, Naproxen and Ibuprofen - several hydrophilic and amphiphillic polymers have been explored and evaluated. The methods of synthesis of the nanodispersions include wet chemical methods like solvent evaporation, microemulsion followed by solvent extraction, and nanoprecipitation and ball milling and a few solvent-free synthetic procedures like microwave heating and hot melt extrusion. The characterization techniques used to evaluate the nature, purity of phase and other properties of the nanodispersions include FTIR, PXRD, DSC and FESEM. Further evaluation of the behavior of the nanodispersions has been done by incorporating them in the most popular oral dosage form, i.e. tablets, and testing the dissolution profiles and assessing the drug release rates from them. Accelerated stability studies were performed on the tablets to establish the storage stability of the nanodispersions over a time of 3 to 6 months.