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Soraya Siabani

Ass.professor in Public health school Kermanshah University of Medical Sciences(KUMS) & Registered External Supervisor at the University technology Sydney

Title: Histopathology criteria suggesting Microsatellite instability in colorectal cancer in Iranian patients

Biography

Biography: Soraya Siabani

Abstract

Background and aim: Colorectal cancer is the third most common cancer and significant cause of death worldwide. Microsatellite instability (MSI) mostly is a characteristic feature of familial colorectal cancer that helps doctors to predict the prognosis, select drugs of choice and ask for genetic consultation looking for hereditary colorectal cancers. This study aimed to investigate histopathology features of colorectal carcinoma suggesting MSI, based on revised Bethesda guideline among Iranian patients.

Material and method: In this analytical cross-sectional study, 230 patients with colorectal cancer, registered at Imam Hossein hospital in Tehran (April 2010 to March 2016) were participated.  The tumour tissue samples were explored, by a skilful pathologist, for tumour infiltrating lymphocyte, crohn’s like peritumoral infiltration,Mucinous differentiation, signet ring cell differentiation and medullary growth pattern. The relationship between those variables and Sex, age, tumor site, tumor size, regional lymph nodes, Dirty necrosis, Intratumoral heterogeneity, Lymphovascular invasion, perineural invasion, microscopic tumor extension (pT), Grade and stage were analysed using SPSS and applying biostatistic tests including Chi-squair and t-test. Alpha less than 0.05 was consider as significant relationship between variables when ever applying.

Results: The findings indicated that the most common histopathologic feature suggesting MSI in Iranian patients is tumour infiltrating lymphocytes and also there is significant relationship between these features and patient age, tumour size, absence of perineural invasion, high grade histology and histological differentiation of adenocarcinoma.

Conclusion: Concerning the limitations of this study including unavailable adequate information about patients’ therapeutic possess, existing metastasis and medical family history, further studies, cohort and registry studies, in particular would be recommended.

Key words: Colorectal carcinoma; Microsatellite instability; lynch syndrome; histopathology; revised Bethesda guideline; Iran