Gautam Sethi
National University of Singapore, Singapore
Biography
Gautam Sethi has completed his Postdoctoral training at University of Texas MD Anderson Cancer Center and joined Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore in 2008 as an Assistant Professor and was promoted to Associate Professor in 2015. The focus of his research over the past few years has been to elucidate the mechanisms of activation of oncogenic transcription factors such as NF-kB/STAT3 by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. From traditional Chinese and Indian medicinal plants, his group has identified numerous small molecules that can suppress various pro-tumorigenic signaling cascades involved in cancer initiation and promotion. The novel findings of his research work have so far resulted in more than one fifty scientific publications in high impact factor peer-reviewed journals and several international awards. He currently serves as an Academic Editor for prestigious PLOS ONE journal and ad-hoc Reviewer for several other international journals.
Abstract
Abstract : Targeted inhibition of transcription factor STAT3 for the prevention and treatment of cancer