Li-Ming Chen
Huazhong University of Science and Technology, China
Title: Physiological roles of Na+/HCO3 – Co-transporters in intracellular pH regulation
Biography
Biography: Li-Ming Chen
Abstract
The solute carrier 4 family (SLC4), which includes the products of ten genes, plays critically important roles in the regulation of acid-base homeostasis. Among theten SLC4 members, eight are well established HCO3 – transporters, including threeNa+-independent anion exchangers (AE1−AE3) and fiveNa+-coupled HCO3 –transporters (NCBTs). The NCBTs consist of two electrogenic NBCe1 and NBCe2 aswell as three electro neutral NBCn1, NBCn2, and NDCBE. NCBTs are broadly expressed in diverse tissues in the body. The pathological significance of the NCBTs has been well established with the demonstrated association of dysfunctions of NCBTs with a series of human diseases, such as severe metabolic acidosis, epilepsy, migraine, mental retardation, visual abnormalities, bone formation defects, breast cancer, cardiovascular diseases, etc. In the present talk, I will discuss the structure and function of NCBTs. I will also discuss the latest progress in our study about the physiological roles of NCBTs in the kidney.
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